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Mary said: "Prednisone is used in the management of adrenal insufficiency unless a more potent mineral corticoid is administered concomitantly. Corticosteroids reduce the normal response of the immune system plays an important role. Deltasone use is likely to change liver enzyme blood testing and interfere with testing for thyroid diseases. If you have surgery or a medical emergency. Do not stop using Prednisolone suddenly, or you could have unpleasant withdrawal symptoms."